20-inch Pharmaceutical Grade Filter Cartridges: Clarification Filter Cartridges for Oral Liquid Extracts
Product Introduction
These 20-inch pharmaceutical grade filter cartridges are professionally engineered as dedicated clarification filtration components for oral liquid extracts, manufactured in strict compliance with pharmaceutical GMP, USP Class VI and FDA 21 CFR 177.1520 standards to meet the high hygiene and purification requirements of oral liquid pharmaceutical production. Crafted from high-purity pharmaceutical-grade polymer materials, the cartridges adopt a precision forming process with an adhesive-free integral structure, eliminating secondary pollution risks from additives. Specifically designed for the clarification stage of oral liquid extracts, they efficiently remove insoluble particulate impurities, suspended solids, colloidal substances and fine sediment from traditional Chinese medicine, chemical and plant oral liquid extracts, improving the clarity and transmittance of extracts, and laying a solid foundation for subsequent concentration, formulation and filling processes of oral liquid products. The 20-inch standard specification is perfectly matched with the mainstream sanitary filter housings in pharmaceutical production workshops, realizing easy installation and stable continuous operation in industrial production lines.
Filtration Precision
Targeting the clarification needs of oral liquid extracts with different viscosity and particulate content, these filter cartridges provide a series of precise and customizable filtration precision options, with nominal filtration ratings ranging from 0.45 μm to 20 μm. The 0.45 μm and 1 μm high-precision models are ideal for the fine clarification of clear oral liquid extracts, achieving the interception of submicron fine particulates to ensure the high transmittance of finished oral liquids; the 5 μm, 10 μm and 20 μm models are suitable for the coarse clarification of high-viscosity, high-particulate oral liquid extracts (such as traditional Chinese medicine decoction extracts), effectively removing large and medium-sized particulate impurities to reduce the filtration load of subsequent fine filtration processes. All precision models maintain stable interception efficiency, without particle leakage under the recommended operating conditions, meeting the clarification quality requirements of pharmaceutical oral liquid production.
Flux
The flux performance of these 20-inch pharmaceutical grade filter cartridges is optimized for the physical properties of oral liquid extracts (e.g., viscosity, density) and industrial continuous production demand, with a pure water flux of 40-80 L/min at 25℃ and 0.1MPa operating pressure, and a practical flux of 10-30 L/min for oral liquid extracts with normal viscosity (≤50 mPa·s) under the same working conditions. The flux shows a moderate and linear decrease with the increase of extract viscosity and the reduction of filtration precision, and remains stable without sudden attenuation in the recommended operating pressure range. The 20-inch long effective filtration area design significantly improves the unit flux, fully meeting the large-volume continuous clarification demand of oral liquid extract production lines.
Salt Rejection Rate
As a dedicated clarification filter cartridge for oral liquid extracts, the product is designed for the interception of insoluble particulate and colloidal impurities, and has no salt rejection function, with a salt rejection rate close to 0%. It does not intercept soluble active ingredients, inorganic salts, small molecular weight active substances and nutrient components in oral liquid extracts (such as polysaccharides, alkaloids, amino acids in traditional Chinese medicine extracts), ensuring that the effective components of the extracts are not lost during the clarification process, and maximizing the retention of the medicinal value and quality of oral liquid products. The product abandons the desalination design to focus on clarification performance, which is the core design feature distinguishing it from water purification desalination filter elements.
Pressure Drop
The product features an optimized low-resistance structural design, with an initial pressure drop of ≤0.015MPa at 25℃ and rated pure water flux for all filtration precision specifications, which effectively reduces the energy consumption of the extract delivery pump in the oral liquid production line and avoids the damage of excessive pressure to the active components of heat-sensitive extracts. With the progress of clarification filtration, the pressure drop gradually increases as the filter surface and internal interception of impurities increase; the recommended terminal operating pressure drop is ≤0.07MPa. When the pressure drop exceeds this value, the filtration flux will decrease significantly, and the cartridge needs to be cleaned or replaced in time to ensure the smooth progress of the extract clarification process and avoid the increase of production cost caused by low efficiency.
Molecular Weight Cutoff (MWCO)
Combined with the filtration precision and structural design of the clarification filter cartridge for oral liquid extracts, the optimized Molecular Weight Cutoff (MWCO) range is 50,000 Da to 300,000 Da. This MWCO range is precisely matched with the physical characteristics of oral liquid extract components: it can effectively intercept macromolecular colloids, macromolecular particulate impurities and insoluble polymer substances in the extracts, while allowing small and medium molecular weight active pharmaceutical ingredients (API), soluble nutrients and water molecules to pass through smoothly. The accurate MWCO setting avoids the interception of effective components and the leakage of harmful macromolecular impurities, achieving the dual goal of efficient clarification and maximum retention of active ingredients.
Membrane Thickness
The 20-inch pharmaceutical grade filter cartridge adopts a gradient thickness filtration layer design, with an effective functional filtration layer thickness of 4-9 mm, and the total outer diameter thickness of the cartridge (including the sanitary inner core and the gradient filtration layer) is a standard 28-30 mm, which is fully compatible with the installation size of sanitary quick-connect filter housings in pharmaceutical workshops. The outer layer of the filtration layer is a loose structure with moderate thickness for coarse interception of large particulate impurities, and the inner layer is a dense fine structure with precise thickness for fine interception of small particulates and colloids. The uniform thickness distribution of the whole filtration layer avoids local excessive pressure and filtration layer damage, and the thickened effective filtration layer significantly improves the dirt-holding capacity and service life of the cartridge, adapting to the long-term continuous production demand of oral liquid extract lines.
Replacement Cycle
The replacement cycle of the 20-inch pharmaceutical grade clarification filter cartridge is determined by the particulate content, viscosity of oral liquid extracts, operating flux and system pressure drop, with a recommended normal replacement cycle of 7-30 days for the oral liquid extract clarification stage in pharmaceutical production. For low-viscosity, low-particulate clear oral liquid extracts (e.g., chemical oral liquid extracts) and intermittent production conditions, the replacement cycle can be appropriately extended to 15-30 days; for high-viscosity, high-particulate traditional Chinese medicine plant extracts and 24-hour continuous industrial production lines, the replacement cycle is shortened to 7-15 days. In addition, when the terminal pressure drop of the cartridge exceeds 0.07MPa, the filtration flux drops by more than 30% of the initial value and cannot be recovered after physical cleaning (e.g., backwashing), or the clarity of the filtered extract fails to meet the production quality standard, the cartridge must be replaced immediately to ensure the stable quality of oral liquid extract clarification.
Features
Features- Pharmaceutical-grade high-purity raw materials: The whole cartridge is made of USP Class VI/FDA certified pharmaceutical-grade polymer materials, free of heavy metals, plasticizers, adhesives and other harmful substances, meeting the hygiene and safety requirements of oral liquid pharmaceutical production.
- Adhesive-free integral structure: The precision forming process without any adhesives eliminates the risk of adhesive component dissolution into the extract, ensuring the purity of oral liquid raw materials and avoiding adverse effects on product quality and human health.
- Gradient filtration layer design: The outer coarse and inner fine gradient structure not only realizes multi-stage efficient interception of impurities of different particle sizes, but also greatly improves the dirt-holding capacity, reduces the replacement frequency and lowers the production operating cost.
- Excellent chemical compatibility: Resistant to most organic solvents, weak acids, weak alkalis and polar solvents commonly used in oral liquid production, adaptable to the clarification filtration of various types of oral liquid extracts (traditional Chinese medicine, chemical, plant, animal source).
- Sanitary standard design: The smooth end cap sealing surface and standard 20-inch specification are perfectly matched with pharmaceutical sanitary quick-connect filter housings, realizing seamless connection, avoiding dead corners and microbial breeding, and complying with GMP production management requirements.
- Good mechanical stability: The integral structure has high compressive and tensile strength, no deformation or damage under the recommended operating pressure and temperature, and can adapt to the continuous and stable operation of industrial production lines.
- Easy to clean and replace: The surface of the filtration layer is smooth, easy to carry out physical cleaning such as backwashing, and the standard specification design realizes quick disassembly and assembly, reducing the downtime of the production line and improving production efficiency.
Application Fields
These 20-inch pharmaceutical grade clarification filter cartridges are specially developed for the oral liquid pharmaceutical production industry, and are widely applied to the clarification filtration stage of various oral liquid extracts, covering the core production links of oral liquid products: clarification filtration of traditional Chinese medicine oral liquid extracts (decoction, alcohol precipitation, water precipitation extracts); fine clarification of chemical oral liquid raw material extracts; purification and clarification of plant/animal source oral liquid extracts (such as propolis, ginseng, cordyceps oral liquid extracts); clarification filtration of health care oral liquid extracts; pre-clarification of oral liquid extracts before concentration and formulation; clarification filtration of semi-finished oral liquid products before filling. In addition, the product can also be used for the clarification filtration of low-viscosity liquid pharmaceutical raw materials in small and medium-sized pharmaceutical workshops, complying with the GMP production standards of the pharmaceutical industry in all application scenarios, and is an indispensable core filtration component for oral liquid pharmaceutical production.
Conclusion
In summary, these 20-inch pharmaceutical grade filter cartridges are high-performance dedicated clarification filtration products tailored for the oral liquid extract production process, with the core advantages of pharmaceutical-grade material safety, precise filtration precision, low pressure drop, high dirt-holding capacity and excellent chemical compatibility. The product can efficiently remove insoluble particulate and colloidal impurities in oral liquid extracts on the premise of maximizing the retention of active pharmaceutical ingredients, significantly improving the clarity and transmittance of extracts, and ensuring the stable quality of subsequent oral liquid concentration, formulation and filling processes. The standard 20-inch specification is fully compatible with the mainstream sanitary filter equipment in pharmaceutical workshops, and the flexible replacement cycle adapts to the production characteristics of different types of oral liquid extracts. As a GMP-compliant filtration component, it effectively solves the pain points of impurity removal and active ingredient retention in the clarification of oral liquid extracts, and is a reliable and cost-effective filtration solution for the oral liquid pharmaceutical production industry, providing strong technical support for the high-quality and efficient production of oral liquid products.
Related products
- 10/30/40-inch Pharmaceutical Grade Clarification Filter Cartridges: Same series filter cartridges with different standard specifications, adaptable to the filtration demand of oral liquid extract production lines with different processing volumes and filter housing models.
- Pharmaceutical Grade Pleated PTFE Filter Cartridges: High-precision fine filtration components for the post-clarification stage of oral liquid extracts, with 0.22 μm ultra-high precision, realizing sterile filtration of oral liquid semi-finished products before filling.
- Pharmaceutical Grade PP Melt Blown Filter Cartridges: Coarse filtration components for the pre-clarification stage of high-particulate oral liquid extracts, effectively removing large particulate impurities and reducing the filtration load of fine clarification filter cartridges.
- Sanitary Grade Stainless Steel Filter Housings (Single/Multi-core): Special matching filter housings for 20-inch pharmaceutical grade filter cartridges, complying with GMP standards, with smooth inner walls and quick-connect design, suitable for industrial production lines of oral liquid extracts.
- Pharmaceutical Grade Activated Carbon Filter Cartridges: Used in conjunction with clarification filter cartridges, adsorbing pigments, peculiar smell and residual organic solvents in oral liquid extracts, further improving the purity and sensory quality of extracts.
- Pharmaceutical Grade Ultrafiltration (UF) Membrane Modules: Deep purification components for high-end oral liquid extracts, intercepting macromolecular impurities and microorganisms while retaining small molecular weight active ingredients, realizing high-purity clarification of extracts.
- Pharmaceutical Grade Silicone Gaskets/Sealing Rings: Sanitary matching accessories for filter cartridges and filter housings, ensuring the sealing performance of the filtration system and avoiding leakage and microbial pollution during the extract filtration process.
