Product Introduction
This security filtration PP filter cartridge is a high-specification professional filtration component exclusively engineered for the security filtration link of central water purification systems in pharmaceutical workshops, manufactured in strict compliance with USP Class VI, FDA 21 CFR 177.1520, EU GMP and Chinese Pharmacopoeia (ChP) standards for pharmaceutical water treatment systems. Crafted from high-purity pharmaceutical-grade polypropylene (PP) fiber with ultra-low leachable substance content, the cartridge adopts an advanced high-precision gradient winding process combined with an adhesive-free hot-melt integral sealing structure, optimized for the core demand of security filtration in pharmaceutical central water purification systems—intercepting fine residual impurities to protect core water treatment equipment and ensure the compliance of pharmaceutical water quality. It efficiently captures fine suspended solids, micro-particulates, colloidal aggregates, rust micro-particles and insoluble impurity residues from the water stream in all stages of pharmaceutical central water purification systems (including pre-treatment, desalination and polishing), preventing the fouling, abrasion and blockage of subsequent core equipment such as RO membranes, UF modules, ion exchange resins and precision filter elements. The product features a high dirt-holding capacity, stable filtration performance and GMP-compliant structural design, perfectly matched with the security filtration units of central water purification systems in pharmaceutical workshops of all scales, realizing reliable and continuous security filtration, reducing the operating failure rate of core water treatment equipment, and laying a solid foundation for the stable, compliant and efficient operation of pharmaceutical central water purification systems and the production of pharmaceutical water meeting pharmacopoeia standards.
Filtration Precision
Targeting the differentiated security filtration requirements of different process links in pharmaceutical workshop central water purification systems and the strict impurity control standards of pharmaceutical water, this security filtration PP filter cartridge provides dedicated and precise filtration precision options, with nominal filtration ratings ranging from 1 μm to 50 μm—the core specification range for efficient fine impurity interception in pharmaceutical water security filtration. The 1 μm, 5 μm and 10 μm high-precision models are customized for the post-desalination and polishing security filtration links of central water purification systems (e.g., WFI and high-purity purified water preparation), intercepting micro-fine particulates and colloidal aggregates to ensure the high purity and clarity of final pharmaceutical water; the 20 μm, 30 μm and 40 μm medium-precision models are applied to the pre-desalination security filtration link (e.g., before RO/UF modules), capturing fine residual impurities in pretreated raw water to protect core desalination membrane elements from fouling and abrasion; the 50 μm coarse-precision model is designed for the primary security filtration link of central water purification systems with high-turbidity raw water inflow, intercepting relatively large fine impurities to reduce the filtration load of subsequent high-precision security filtration links. All precision models maintain consistent and non-attenuating interception efficiency under the dynamic water flow conditions of pharmaceutical central water purification systems, with zero particle penetration and no fiber shedding, fully meeting the stringent security filtration quality requirements of the pharmaceutical industry for central water purification systems in workshops.
Flux
The flux performance of this security filtration PP filter cartridge is fully optimized for the large-flow characteristics of central water purification systems in pharmaceutical workshops and the low-resistance demand of security filtration links, with a pure water flux of 60-150 L/min·m² at 25℃ and 0.1MPa operating pressure—a balanced design of high flux and stable filtration precision adapted to pharmaceutical water treatment. For the standard 10-inch cartridge, the initial pure water flux reaches 8-20 L/min; the 20-inch cartridge is 16-40 L/min, and the 40-inch large-specification cartridge can reach 32-80 L/min, perfectly matching the water supply demand of central water purification systems in small, medium and large-scale pharmaceutical workshops (from laboratory pilot workshops to large-scale industrial production workshops). For actual pharmaceutical water treatment streams (pretreated raw water, RO inlet water, polished water precursor), the actual working flux is basically consistent with the pure water flux, and the flux attenuation rate remains extremely low during long-term use due to the optimized high dirt-holding capacity design. The low-resistance gradient filtration channel design ensures that the flux does not decrease sharply with the reduction of filtration precision, and the stable flux performance meets the continuous large-flow water supply demand of pharmaceutical workshop production lines without causing pressure loss or water supply fluctuation in the central water purification system, ensuring the stable operation of subsequent pharmaceutical production processes.
Salt Rejection Rate
As a dedicated security filtration PP filter cartridge for pharmaceutical workshop central water purification systems, the product is designed only for the physical interception of insoluble fine particulate, colloidal and aggregate impurities in the water stream, and does not have any desalination, ion removal or dissolved substance retention function, with a salt rejection rate close to 0%. It neither intercepts soluble inorganic salts, minerals, small molecular weight organic substances nor affects the pH value, conductivity, total organic carbon (TOC) and other key chemical quality indices of pharmaceutical water specified in pharmacopoeias, and has no impact on the subsequent desalination, purification and polishing efficiency of central water purification systems. The desalination and ion removal of pharmaceutical water are exclusively undertaken by core equipment such as RO membranes, nanofiltration membranes and ion exchange resins in the central water purification system; the core function of this security filtration cartridge is to remove insoluble fine impurities in advance to avoid the pollution, abrasion and irreversible fouling of core desalination and purification equipment, ensuring their long-term stable operation and consistent desalination efficiency. The abandonment of desalination design makes the cartridge focus on fine impurity interception with a high-flux and low-resistance structure, which is the key to realizing its reliable security filtration performance adapted to pharmaceutical central water purification systems.
Pressure Drop
The product adopts an optimized ultra-low resistance high-precision gradient winding structure and high-fluidity pharmaceutical-grade PP fiber material, with an initial pressure drop of ≤0.009MPa at 25℃ and rated pure water flux for all filtration precision specifications—far lower than the industry standard for pharmaceutical security filtration cartridges. This ultra-low initial pressure drop effectively reduces the energy consumption of the circulating and delivery pumps in pharmaceutical central water purification systems, avoids excessive pressure loss in the security filtration link, and ensures the normal hydraulic pressure of subsequent core water treatment equipment and the stable water supply pressure of pharmaceutical workshop production lines. During long-term use, the pressure drop of the cartridge increases in a slow and linear manner with the gradual accumulation of intercepted fine impurities, rather than a sudden sharp rise; the recommended terminal operating pressure drop is uniformly set to ≤0.06MPa for all precision models. The slow pressure drop rise rate is a core advantage of this cartridge, which allows for longer continuous use time, reduces the frequency of shutdown and replacement operations for the security filtration system, and ensures the uninterrupted operation of pharmaceutical central water purification systems and the continuous production of pharmaceutical workshops. Even for water streams with slight residual impurity fluctuations, the pressure drop rise rate remains stable, avoiding sudden pressure changes in the central water purification system caused by impurity accumulation.
Molecular Weight Cutoff (MWCO)
Combined with the filtration precision, high-precision gradient winding density and the fine impurity characteristics of pharmaceutical workshop central water purification system water streams, the optimized Molecular Weight Cutoff (MWCO) range is 30,000 Da to 300,000 Da for this security filtration PP filter cartridge, specially tailored for the interception of fine macromolecular colloidal and particulate aggregate impurities in pharmaceutical water treatment streams. This MWCO range is precisely designed for the physical interception of insoluble fine impurities in pharmaceutical water, and can effectively capture macromolecular impurities such as colloidal protein aggregates, clay micro-colloid clusters, rust particle micro-aggregates, fiber micro-polymers and other insoluble fine impurities (MW > 30,000 Da) in all water treatment stages of the central purification system, while allowing all small and medium molecular weight substances (water molecules, inorganic salts, dissolved small molecular weight organic substances) and compliant dissolved components in pharmaceutical water to pass through smoothly. For different filtration precision models, the MWCO range is adaptively and precisely adjusted: the 1/5/10 μm high-precision models have a MWCO of 30,000 Da-100,000 Da for intercepting ultra-fine macromolecular colloids and micro-particulate aggregates; the 30/50 μm medium-coarse precision models have a MWCO of 200,000 Da-300,000 Da for capturing fine particulate aggregates and residual colloids. The stable MWCO setting without deviation during long-term use ensures efficient and selective interception of fine impurities in the water stream, without affecting the chemical composition and key quality indices of pharmaceutical water, and fully meets the pharmacopoeia requirements for pharmaceutical water quality.
Membrane Thickness
This security filtration PP filter cartridge adopts a reinforced gradient thickness filtration layer design specially adapted to the large-flow, fine impurity interception characteristics of pharmaceutical workshop central water purification systems and the demand for high dirt-holding capacity, with an effective functional filtration layer thickness of 5-12 mm—a balanced design of structural stability, filtration precision and impurity storage capacity. The total outer diameter thickness of the cartridge (including high-strength pharmaceutical-grade PP inner core and gradient filtration layer) is a standard 28-30 mm, fully compatible with the installation size of security filtration unit filter housings in all types of pharmaceutical workshop central water purification systems, complying with the standardized equipment design requirements of pharmaceutical GMP workshops. The filtration layer is composed of a loose and wear-resistant outer layer (2-5 mm) with optimized pore size for the primary interception of fine particulate aggregates and residual colloids, and resistance to the continuous scouring of large-flow water streams in the central purification system; a medium-density middle layer (2-4 mm) for the secondary interception of fine particulates and macromolecular colloidal clusters, maximizing the dirt-holding capacity of the cartridge and delaying flux attenuation; and a dense and high-precision inner layer (1-3 mm) for the ultra-fine interception of micro-particulates and colloidal aggregates, ensuring the filtration precision corresponding to different models. The whole filtration layer is formed by high-precision winding and one-piece hot-melt bonding, with uniform thickness distribution and excellent structural stability, avoiding local excessive pressure and filtration layer damage caused by the large-flow scouring of water streams, and the reinforced thickness design significantly improves the cartridge’s ability to bear fine impurity accumulation and extend its service life in security filtration links.
Replacement Cycle
The replacement cycle of this security filtration PP filter cartridge is scientifically designed according to the process link, water stream impurity content, daily water supply volume and filtration precision of pharmaceutical workshop central water purification systems, with a recommended normal replacement cycle of 3-10 weeks for the security filtration link—flexibly adjustable according to the actual operating conditions of the central water purification system and the GMP management requirements of pharmaceutical workshops. For the post-desalination and polishing security filtration links (1/5/10 μm models) with ultra-low impurity content water streams and stable operating conditions, the replacement cycle can be appropriately extended to 8-10 weeks, complying with the low-frequency maintenance requirements of high-purity pharmaceutical water preparation links; for the pre-desalination security filtration links (20/30/40 μm models) with medium impurity content water streams and large daily water supply volume, the replacement cycle is 5-7 weeks; for the primary security filtration links (50 μm models) with relatively high residual impurity content water streams and industrial-scale daily water supply volume, the replacement cycle is still maintained at 3-5 weeks for all operating conditions. The cartridge only needs to be replaced immediately when the terminal pressure drop exceeds 0.06MPa, the filtration flux drops by more than 30% of the initial value and cannot be recovered after backwashing, or the water quality of the subsequent link fails to meet the pharmaceutical water pretreatment index requirements; regular replacement within the recommended cycle is combined with the GMP regular maintenance plan of pharmaceutical workshops, which greatly reduces the replacement frequency and production downtime of the security filtration system, and ensures the compliant operation of the central water purification system in line with pharmaceutical GMP requirements.
Features
- Pharmaceutical-grade high-purity raw materials: The whole cartridge is made of USP Class VI/FDA certified high-purity pharmaceutical-grade PP fiber, with ultra-low leachable substance content, no heavy metals, plasticizers or organic volatile compounds, meeting the strict hygiene and chemical purity requirements of pharmaceutical water treatment in GMP workshops.
- Adhesive-free hot-melt integral sealing: Advanced one-piece hot-melt bonding process without any adhesives, binders or sealants, eliminating dead corners for microbial breeding and the risk of chemical additive leaching into the water stream, complying with the GMP production and on-site management standards of pharmaceutical workshops.
- High-precision gradient porous filtration structure: The outer loose, middle medium and inner dense gradient porous structure realizes multi-stage interception of fine impurities of different sizes in the water stream, maximizes the dirt-holding capacity, avoids rapid filter layer blockage, and ensures stable filtration precision for a long time.
- Ultra-low initial pressure drop & stable flux: Optimized low-resistance filtration channel and high-fluidity PP fiber design ensure ultra-low initial pressure drop and low flux attenuation rate during long-term use, adapting to the large-flow water supply demand of pharmaceutical workshop central water purification systems and reducing energy consumption.
- Excellent resistance to water stream scouring: The wear-resistant reinforced filtration layer and high-precision winding structure have strong resistance to the continuous scouring of large-flow water streams in the central purification system, no fiber shedding, no filter layer damage and no filtration precision attenuation during long-term operation.
- Superior chemical compatibility with pharmaceutical water: Resistant to most inorganic salts, weak acids, weak alkalis, residual chlorine and trace organic substances in pharmaceutical water treatment streams, maintaining stable physical and chemical properties without material dissolution or structural damage, adapting to all water treatment stages of central purification systems.
- High mechanical stability & pressure resistance: The integral reinforced structure has excellent compressive strength (resistant to 0-0.5MPa operating pressure), no deformation or structural damage under the hydraulic pressure of central water purification system pumps, and can work stably in the temperature range of 0-60℃, adapting to the harsh operating environment of pharmaceutical water treatment systems.
- GMP-compliant structural design: Smooth surface, no dead corners, standard sanitary structural design, compatible with CIP (Clean-in-Place) cleaning processes of pharmaceutical water treatment systems, meeting the GMP cleaning and sterilization requirements of pharmaceutical workshops.
- Backwashable & reusable: The pharmaceutical-grade PP fiber filter layer is easy to carry out physical backwashing with purified water or compressed air, and the cleaned cartridge can be reused for a short time, further reducing the operation and maintenance cost of the central water purification system under the premise of complying with GMP standards.
- Standard industrial specification & universal installation: Standard 28-30 mm outer diameter and mainstream 10/20/40-inch length specifications, perfectly matched with security filtration unit filter housings in all types of pharmaceutical workshop central water purification systems, no additional modification of existing GMP workshop equipment, quick installation and replacement, reducing production downtime.
